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The internet speeds available to you are largely dependent on where you live. According to Ookla, the global median download speed for fixed broadband is roughly 60 Mbps download and 25 Mbps upload. In the U.S., the median is about 135 Mbps down and 20 Mbps up.
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The internet speeds available to you are largely dependent on where you live. According to Ookla, the global median download speed for fixed broadband is roughly 60 Mbps download and 25 Mbps upload. In the U.S., the median is about 135 Mbps down and 20 Mbps up.\n"}},"@type":"Question","name":"How Fast Is a Good WiFi Speed?","acceptedAnswer":"@type":"Answer","text":"You\u2019ll always lose out on some bandwidth with a WiFi network as opposed to a wired connection. How much depends on a multitude of factors like your hardware, signal interference and even the materials your house is made out of.\n","@type":"Question","name":"Is 100 Mbps Fast Internet?","acceptedAnswer":"@type":"Answer","text":"Yes, for the vast majority of people, a 100 Mbps connection will feel very fast and have more than enough bandwidth.\n"]}What Is a Good Internet Speed for General Use?A good internet speed depends almost entirely on what you intend to use it for. In general, a high internet speed is most useful for video calls or meetings, streaming video, gaming online, live streaming and downloading large files. If we over-simplify things, most users with just one or two devices will experience anything over 50 megabits per second (Mbps for short) as fast.
For the vast majority of users, download speed will be the most important, as most people receive far more data than they send. However, for things like live streaming, online gaming and video calls, upload speeds are also crucial.
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Note that --full-remote-verification does not verify everything at the backend, it checks the entire content of a remote file instead of just verifying the file hash.The default number of remote files to verify after each backup is one (!). By supplying all to the verify command as the number of samples, all remote files will be downloaded and verified.
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Paper copies of the network provider directory are available at no cost to members by calling the customer service number on the back of your ID card. Non-members may download and print search results from the online directory.
Triple-negative breast cancer (TNBC) is the most complex and aggressive type of breast cancer encountered world widely in women. Absence of hormonal receptors on breast cancer cells necessitates the chemotherapy as the only treatment regime. High propensity to metastasize and relapse in addition to poor prognosis and survival motivated the oncologist, nano-medical scientist to develop novel and efficient nanotherapies to solve such a big TNBC challenge. Recently, the focus for enhanced availability, targeted cellular uptake with minimal toxicity is achieved by nano-carriers. These smart nano-carriers carrying all the necessary arsenals (drugs, tracking probe, and ligand) designed in such a way that specifically targets the TNBC cells at site. Articulating the targeted delivery system with multifunctional molecules for high specificity, tracking, diagnosis, and treatment emerged as theranostic approach. In this review, in addition to classical treatment modalities, recent advances in nanotheranostics for early and effective diagnostic and treatment is discussed. This review highlighted the recently FDA approved immunotherapy and all the ongoing clinical trials for TNBC, in addition to nanoparticle assisted immunotherapy. Futuristic but realistic advancements in artificial intelligence (AI) and machine learning not only improve early diagnosis but also assist clinicians for their workup in TNBC. The novel concept of Nanoparticles induced endothelial leakiness (NanoEL) as a way of tumor invasion is also discussed in addition to classical EPR effect. This review intends to provide basic insight and understanding of the novel nano-therapeutic modalities in TNBC diagnosis and treatment and to sensitize the readers for continue designing the novel nanomedicine. This is the first time that designing nanoparticles with stoichiometric definable number of antibodies per nanoparticle now represents the next level of precision by design in nanomedicine.
Liposomes are spherical vesicles (400 nm) molecule with central aqueous core surrounded by lipid bilayers (Table 1). The feasibility to encapsulate drug either in lipid membrane or inside the aqueous core, mark the liposomes the most versatile nanocarriers with better drug distribution. Generally, liposomal nanoparticles are designed by the different methods i.e. extrusion (process of producing nanoparticles of fixed cross-sectional area), solvent injection (method of lipid precipitation from a dissolved lipid in solution) and reverse phase evaporation. Dai et al,[28] targeted the over-expressing integrin-α3 in TNBC models with cyclic octapeptide LXY (Cys-Asp-Gly-Phe (3,5-DiF)-Gly-Hyp-Asn-Cys) attached liposomes carrying dual drug i.e. doxorubicin and rapamycin (Table 1). This dual drug targeted approach resulted in improved efficacy as compared to free drug. Similarly, enhanced antitumor activity in TNBC xenograft mice model has shown with doxorubicin and sorafenib loaded liposomes [29]. However, currently marketed doxorubicin liposomal formulations are associated with cardiotoxicity, a novel micelle-encapsulated doxorubicin formulation (NK911) with improved tumour penetration and reduced in vivo toxicity is in trial [30]. Liposomal drug delivery system for co-delivery of antagomir-10b (anti-metastasis) and PTX (anti-cancer) was developed to delay 4T1 tumour growth and reduce the lung metastases of breast cancer [31]. A significant inhibition and reduction of 82% in the tumor growth was observed with PEG coated PTX nanocrystals targeting nude mice (MDA-MB-231/luc) and a lung tumour metastasis model [32]. Much higher i.e. 87% inhibition of breast tumor growth was reported in xenografted mice (MDA-MB-231 cells) by lipid-conjugated estrogenic (bioactive; 47.03%) NPs in combination with cisplatin [33]. So far, paclitaxel and irinotecan loaded liposomes known as EndoTAG-1 and MM-398 reached the way to clinical studies in TNBC patients [34].
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